Tesofensine — Complete Dosing Protocol & Guide

Tesofensine is a weight loss peptide — the weight loss category covers fat loss, appetite control, metabolic health. Triple monoamine reuptake inhibitor (serotonin, noradrenaline, dopamine) that suppresses appetite and increases energy expenditure through central nervous system pathways. In research settings it is administered oral at a frequency of once daily, with an elimination half-life of ~220 hours (~9 days) and a studied dose range of 250 mcg–1 mg per administration (about 3.6 mcg/kg of body weight).

Triple monoamine reuptake inhibitor (serotonin, noradrenaline, dopamine) that suppresses appetite and increases energy expenditure through central nervous system pathways. That mechanism places it in the weight loss category. Pharmacokinetically, its elimination half-life of ~220 hours (~9 days) is what shapes the once daily dosing cadence used in research protocols, and the full effect builds across a 24 weeks cycle followed by 4-8 weeks off — which is why the dosing is cycled rather than continuous.

Tesofensine is taken oral. The research-standard frequency is once daily, with a half-life of ~220 hours (~9 days). Keep administrations on the same day(s) each week so plasma levels stay steady. Always start at the low end of the dose range, use aseptic technique for injections, and follow the 24 weeks cycle followed by 4-8 weeks off. PeptideWise calculates the exact dose and schedule for your body weight and goal.

Research protocols use 250 mcg–1 mg per administration, weight-based at roughly 3.6 mcg/kg of body weight, administered once daily. For an 80 kg (176 lb) adult that works out to about 101 mcg for a beginner, 144 mcg for an intermediate, and 216 mcg for an advanced research protocol. Start at the bottom of the range and titrate up only while the response is tolerable — the personalized protocol engine on this site computes the exact figure for your weight.

The standard research cycle is 24 weeks, followed by 4-8 weeks off. Cycling matters because continuous exposure leads to receptor desensitization (tachyphylaxis) — the same dose produces less effect over time — and side effects fade during off periods. Don't extend the cycle past 24 weeks chasing diminishing returns.

Yes. Tesofensine is commonly researched alongside MOTS-c, AOD-9604. The best stacks pair peptides that act through different mechanisms toward the same goal — for example BPC-157 (angiogenesis) with TB-500 (cell migration). Introduce one peptide at a time, align cycle lengths, and cap stacks at 2–3 peptides so effects stay attributable. The protocol engine on this site only recommends stack combinations that pass safety screening for your conditions and medications.

Reported in research and trial settings: dry mouth; insomnia; increased heart rate; constipation; mood changes. Most are dose-dependent and resolve when the dose is reduced or the cycle ends. If any severe reaction occurs (chest pain, severe abdominal pain, difficulty breathing, signs of an allergic response), stop immediately and seek medical evaluation.

Tesofensine carries a good research safety profile at the doses described above, but safety is individual. It is contraindicated in research settings with: heart condition, high blood pressure, cardiovascular disease, pregnant, breastfeeding, ssri, maoi. It is not medical advice to run any peptide without supervision — consult a qualified healthcare provider who knows your full history first, get baseline labs, and re-check during the cycle. 🔥 As a weight loss peptide, Tesofensine is sold for research use only.

Tesofensine is sold by research-chemical suppliers for laboratory research use only — it is not an approved dietary supplement or consumer product, and regulations vary by country and jurisdiction. Before considering any source: (1) consult a licensed healthcare provider about medically supervised options, (2) if purchasing for research, verify third-party certificates of analysis (COA) confirming purity and identity, and (3) be wary of prices that look too good to be true — they usually are. PeptideWise does not sell peptides; we provide dosing research and protocol tools.

Tesofensine is taken orally, so no reconstitution is needed — it is dosed directly as a capsule or measured powder per the research protocol. Our general reconstitution guide (bacteriostatic water, concentration math, storage) applies to the injectable peptides in the database.